Forskolin herbal supplements are trending as controversial weight loss supplements. While research studies show that the impact of forskolin on weight loss is limited, this natural plant compound has been used as a herbal remedy for cardiovascular, respiratory, and gastrointestinal problems in India for many years.
Apart from widely being used as a weight loss supplement, it has many benefits like lowering blood pressure, stimulating cyclic AMP and preventing blood vessel blockage. The following article will discuss potential uses and side effects of forskolin and forskolin derivatives.
What is Forskolin?
Forskolin is a herbal supplement made from a compound that is extracted from the root of the Indian coleus plant (Plectranthus barbatus). This compound is a diterpene and plays a key role in the cyclic AMP cycle in the body, which helps release stored energy during fasting and exercise. It came into the spotlight as a weight-loss supplement in the US after being featured on the Dr. Oz Show, an American show hosted by Dr. Mehmet Oz, in January 2014. Forskolin can also help reduce inflammation and has certain other antioxidant and relaxant properties. Some of the other names for this compound include coleonol, pashanabhedi, coleus forskohlii, colforsin, makandi, and maohouqiaoruihua.
Forskolin has many potentially useful properties:
- It stimulates cyclic AMP
- Lowers blood pressure
- Prevents blockage of blood vessels
- Promotes weight loss
- Relaxes muscles
- Influences hormone release
- Restores function of heart cells
- Lowers inflammation
- Kills different types of cancer cells
Health Benefits of Forskolin
Forskolin Will Help You Lose Weight:
One of the main reasons why people use forskolin is because it is believed that it can positively affect weight loss in the body. This is largely due to the active ingredients in forskolin that can stimulate the process of lipolysis, which is the burning of fat, thus making your workouts more effective. However, studies done on the herbal supplement show mixed results.
In a clinical study by the University of Kansas, a team of researchers investigated the effect of forskolin (250 mg of 10% forskolin extract) taken twice a day on 15 obese and overweight men for 12 weeks.The results were compared with 15 men of a similar weight range who were given dummy pills. The forskolin group lost a significant amount of fat and also saw an increase in their bone mass and testosterone levels, as compared to the placebo group. Increase in testosterone hormone levels also aids in weight loss.
Forskolin For Treating Diabetes:
It is also good for suppressing inflammation, which often worsens the condition in diabetic patients and helps decrease the level of sugar in the blood in rats [R].
Diabetic retinopathy is caused by high levels of sugar that damage small eye vessels and cause blood to leak into the eye and damage vision.
Forskolin Against Cancer:
Some of the most exciting research coming out about this supplement regards cancer, as it is believed that this could be a good supplement to cancer therapy.and metabolism.A report by Dr. Kailash C. Agarwal and Dr. Robert E. Parks Jr from Brown University said that forskolin could help in the prevention of cancer metastasis by improving the strength of the body’s immune system
Forskolin Influences Immune System:
There are several articles showing the influence of forskolin on different parts of the immune system.
It was recently found that forskolin helps killer immune cell development [R].
Other studies, however, show completely opposite findings – that forskolin blocks immune T cell development and immune protein IL-2 [R].
Forskolin does not act by blocking IL-2 directly, as cAMP is actually increasing the level of this protein. It is known to destroy the relationship between proteins that carry information into the cell and activate the development of appropriate changes [R].
It is also known that cAMP can reduce inflammation by suppressing RAGE protein, which initiates the development of inflammation [R].
There is also a report showing that cAMP-elevating drugs, including forskolin, are able to block the production of potentially inflammatory protein GM-CSF [R].
There is also evidence that forskolin induces immune cell production of a number of substances beneficial in treating chronic inflammation [R].
It should be noted that while the immune cells produce some useful proteins, their activity is partly blocked by forskolin [R].
The dual effect of forskolin may be explained by the fact that cAMP selectively drives the development of immune cells in favor of certain types, blocking other types of cells and reactions [R].
Forskolin Is A Good Friend For The Heart:
According to recent research, forskolin can be used to treat heart disease.
First of all, forskolin blocks movement of Ca2+ into muscle cells, thus preventing contraction of muscle cells in the heart and blood vessels. Muscle relaxation is very important in preventing heart attacks [R].
It was also proposed that new forskolin derivative, NKH477, can reverse damage to the heart in rats with heart attack [R].
NKH477 at present is viewed as a promising drug that can make the heart to work at a proper pace [R].
It was also shown in experiments on heart cells that forskolin reverses some defects associated with a type of heart failure called mitral deficiency, which may improve outcomes after heart operations for this type of problem [R].
NKH477 can be also used as a preventive measure during surgery as it prevents heart failure by narcotic drugs used in anaesthesiology [R].
Forskolin derivatives NKH77 and DMAPD increase the level of cAMP in heart cells better than forskolin itself and are more effective for heart therapy [R].
Forskolin Increase Testosterone Levels:
When taking this supplement, testosterone levels are seen to increase, one of the other reasons why this is such a popular accompaniment to workouts for athletes and bodybuilders. However, consuming an excess can wreak havoc on the hormonal balance of the body.
Forskolin Side Effects
- Irregular heart rate
- Higher risk of polycystic ovary syndrome (PCOS)
- Stinging in the eyes
Again, be sure to speak with your doctor before taking this supplement, as the side effects can be quite serious when taken in excess.
Where To Buy Premium Forskolin
You can Get The Most Effective Forskolin Supplement From Forskolin 250 Here Or By Clicking On The Banner Below